7 novel supplements to support longevity, gut health, weight loss, well-being & more
- Radiant Herbal Wellness
- Apr 30
- 4 min read
We live in a fast-paced world, filled with toxins and stressors that can cause physical and emotional overload. The continuous taxing of our bodies from various sources means we're often depleted of the nutrients that can help to keep our bodies strong and resilient.
The truth is, we want to live happier, healthier, more peaceful lives whenever possible, in order to make sure we are functioning at our best.
Supplements can help us to do that, especially if we have any vitamin or mineral deficiencies, or any infections that are robbing us of essential nutrients.
Of course, the best place to start when it comes to establishing a good foundation for health is optimizing nutrition, exercise, and sleep. But beyond that, other supports such as supplements can replenish deficiencies and help to restore the body's innate healing abilities.
The below supplements are stand-out supports to help our bodies function at their best.
(Note: Consult your doctor or health care provider before altering or changing anything in regards to medical prescriptions, diagnosed conditions or supplementation.)
1. Pendulum Akkermansia
Akkermansia is a next-generation probiotic for gut lining and metabolism.
This supplement features a patented live strain of Akkermansia muciniphila, a keystone gut bacterium that's often depleted in modern diets/lifestyles and can't reliably be obtained from food or standard probiotics. It's one of the most innovative microbiome products in the professional space.
Quick facts:
Backed by Stanford/Johns Hopkins research and clinical trials; it directly strengthens the gut barrier, supports GLP-1 production (for metabolic balance), and influences overall microbiome health—unlike generic probiotics.
Benefits: Improved digestion, better metabolic function, reduced inflammation signals, and stronger immune/gut resilience. Ideal for anyone with occasional bloating, energy dips, or wanting foundational gut support (common in ~70-80% of adults per general microbiome trends).
2. Timeline Mitopure (Urolithin A) / Cellular Longevity PRO
Urolithin A is a mitochondrial "recycler" for cellular energy and muscle health. It is a postbiotic metabolite (produced from ellagitannins in pomegranates/walnuts by specific gut bacteria) that's now available in a purified, clinically dosed supplement form. Many people don't produce enough naturally.
Quick facts:
Patented Mitopure form with 15+ years of research and multiple gold-standard human trials showing it triggers mitophagy (clearing damaged mitochondria). It's a leader in the booming cellular/longevity category.
Benefits: Enhanced cellular energy production, better muscle strength/endurance, and support for healthy aging—great for anyone feeling mid-day fatigue, recovering from workouts, or prioritizing longevity without stimulants.
3. Tru Niagen (Nicotinamide Riboside / NR)
An efficient NAD+ booster for cellular repair and vitality, NR is a form of vitamin B3 that raises NAD+ levels (a critical coenzyme that declines sharply with age/stress). Tru Niagen uses a patented, clinically studied version proven more efficient than alternatives in head-to-head data.
Quick facts:
Decades of Nobel-related science on NAD+; it's one of the top-researched anti-aging pathways, with easy-to-use daily capsules that deliver measurable NAD+ increases (often >50% in studies).
Benefits: Supports energy at the cellular level, brain/muscle recovery, and resilience to daily stressors—appealing for busy adults, athletes, or anyone over 30 noticing lower energy or slower recovery.
4. PQQ (Pyrroloquinoline Quinone)
PQQ promotes mitochondrial biogenesis (creating new mitochondria) and works synergistically with CoQ10 or NAD+ boosters.
Quick facts:
Considered a "new vitamin-like" compound with unique antioxidant and neuroprotective properties. Growing research on energy, cognitive support, and anti-aging at the mitochondrial level.
Benefits: Enhanced cellular energy production, neuroprotection, and resilience to oxidative stress—great complement to Urolithin A or NR for anyone experiencing fatigue or brain fog.
Includes PQQ, B1, B2, B6, B12, CoQ10, alpha lipoic acid, NMN & Urolithin A
5. Fisetine
Fisetin is a naturally occurring flavonoid found in fruits and vegetables such as strawberries, apples, persimmons, onions, and grapes. It has gained significant attention in longevity and anti-aging research primarily for its potential as a senolytic—a compound that selectively clears senescent ("zombie") cells, which accumulate with age and contribute to chronic inflammation, tissue dysfunction, and age-related diseases.
Quick facts:
A landmark 2018 study from the Mayo Clinic and collaborators demonstrated that fisetin was the most potent senolytic among 10 flavonoids tested. In aged mice, intermittent fisetin administration reduced senescent cell burden in various tissues, lowered markers of inflammation (including the senescence-associated secretory phenotype or SASP), and extended both healthspan and median lifespan—without reported adverse effects even at high doses.
Benefits: Shows potential to support healthy aging by selectively clearing senescent cells, reducing chronic inflammation, promoting better cardiovascular health, cognitive function, metabolic health, and resilience.
6. HMOs, Human Milk Oligosaccharides
These are complex sugars (like 2'-FL) originally from breast milk, now available as targeted prebiotics that selectively feed beneficial bacteria.
Quick facts:
Beyond standard prebiotics/fiber, HMOs uniquely support Bifidobacteria growth, gut barrier integrity, and immune modulation—even in adults. Emerging adult trials show microbiome and metabolic benefits.
Benefits: Improved gut comfort, immune resilience, and potential metabolic/brain support for most people (especially those with modern diet-related dysbiosis).
7. Spermidine
Spermidine is a polyamine compound (naturally in wheat germ, certain cheeses) that promotes autophagy—the body's cellular "cleanup" process, which slows with age.
Quick facts:
Strong longevity research linking it to cellular renewal, cardiovascular support, and even hormone balance in studies; it's featured in advanced combos with resveratrol, berberine, urolithin A, and NMN for synergistic effects.
Benefits: Supports healthy aging at the cellular level, better recovery, and overall vitality—perfect as a daily "maintenance" addition for energy, skin, or immune health.
Includes Spermadine, fisetin, NMN, PQQ, resveratrol & AMRK/SIRT1 activator
The above supplements stand out because they target root causes (gut dysbiosis, mitochondrial decline, autophagy deficits, NAD+ depletion) that affect nearly everyone in modern life, with strong clinical backing and practitioner-grade quality.
Remember: The foundation to good health is optimizing nutrition, exercise and sleep, reducing stress when possible, and checking for any nutritional deficiencies. Taking time for your health is one of the best ways to improve your life!
About the author
Charis is an AFPA-certified health coach who beat debilitating long Covid and lost 40 pounds. She can help in the areas of chronic illness, weight loss, and bodybuilding. If you are in need of support, please reach out for a consult!
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